Rai Staging System for Chronic Lymphocytic Leukemia
Stage
Clinical Features
0
Lymphocytosis (L) >5,000ml
I
L + enlarged nodes
II
L + hepato-/splenomegaly
(+/- nodes)
III
L + anemia (Hgb < 11g/dl)
(+/- hepato-/splenomegaly;
+/- nodes)
IV
L + thrombocytopenia
(< 100,000ml; +/- nodes;
+/- hepato-/splenomegaly;
+/- anemia)

Reference: Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood. 1975; 46:219-234.


Binet Classification for Chronic Lymphocytic Leukemia
Stage
Clinical Features*
A
L + <3 nodal regions enlarged
B
L + 3 or more nodal regions enlarged
C
L + anemia (Hgb < 10g/dl) and/or platelets < 100,000/ml (+/- nodal enlargement.

* Nodal Regions - maximum of 5 involved regions:

  1. cervical & Waldeyer ring
  2. axillae
  3. inguinal
  4. spleen
  5. liver

Reference: Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981; 48:198-206.

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